Understanding cortical pain perception in humans
نویسندگان
چکیده
منابع مشابه
Cortical representation of first and second pain sensation in humans.
Single painful stimuli evoke two successive and qualitatively distinct sensations referred to as first and second pain sensation. Peripherally, the neural basis of this phenomenon is a dual pathway for pain with Adelta and C fibers mediating first and second pain, respectively. Yet, the differential cortical correlates of both sensations are largely unknown. We therefore used magnetoencephalogr...
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To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change distribution. Contralateral somatosensory rCBF was decreased when the digits ...
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Pain is a highly subjective experience that can be substantially influenced by differences in individual susceptibility as well as personality. How susceptibility to pain and personality translate to brain activity is largely unknown. Here, we report that the functional connectivity of two key brain areas before a sensory event reflects the susceptibility to a subsequent noxious stimulus being ...
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BACKGROUND Research in animal models suggests that transcutaneous electrical nerve stimulation (TENS) and conditioned pain modulation (CPM) produce analgesia via two different supraspinal pathways. No known studies have examined whether TENS and CPM applied simultaneously in human subjects will enhance the analgesic effect of either treatment alone. The purpose of the current study was to inves...
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Cerebral pain mechanisms are poorly understood when compared with the peripheral nervous system and spinal cord. Reasons for this have included a lack of suitable examination techniques, especially in humans. The recent availability of a number of relatively non-invasive methods that can produce images of functional brain activity has renewed interest in this field. Three of these techniques wi...
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ژورنال
عنوان ژورنال: Neurology and Clinical Neuroscience
سال: 2020
ISSN: 2049-4173,2049-4173
DOI: 10.1111/ncn3.12378